EVIDENT: current activities
With all the experimental data gathered in the field, EVIDENT investigators are trying systems immunology approach to look for immune signatures related with Ebola virus disease outcome, in particular signatures related with T cell, NK cell and dendritic cell function, key players in EVD immunity. Our current studies involve analysis of luminex cytokine data, transcriptional profiling, mathematical modeling, genomics, proteomics and high throughput flow cytometry. New experimental approaches also include sequencing of B cell and T cell receptors in collaboration with Tom Kepler and John Connor at the NEIDL (Boston University). These joint efforts and expertise will guarantee gathering as much information as possible from the highly valuable samples collected in the field. A number of joint studies are also expected from these efforts which will hopefully add up to the high impact papers generated by the EVIDENT team so far.